Breakthroughs in Indole and Indolizine Chemistry – New Synthetic Pathways, New Applications
نویسندگان
چکیده
Indole and indolizines (heterocyclic aromatic compounds structurally and chemically isomeric with indoles) are an important class of N-fused heterocyclic compounds due to their interesting biological and optical properties. Different strategies for generating di‐ verse collections of small molecules with indole and indolizine moieties have been de‐ veloped. They can be synthesized by means of classical and nonclassical pathways. The present study discusses the versatile nature of indole/indolizine derivatives, new green methods for their synthesis, their possible mechanism of action and also provides infor‐ mation about current/future prospects of the topics and different indole/indolizine de‐ rivatives in pharmaceutical/clinical trials. With the remarkable number of approved indole-containing drugs as well as the importance of the indolizine moiety, it can be easily concluded that indole and indolizine derivatives offer perspectives on how pyr‐ role scaffolds might be exploited in the future as bioactive molecules against a broad range of diseases.
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